I appreciate the apology but I don't appreciate being lied to. I have never once used your name on this website.
This will be the only thread on Covid here
- Thread starter Halldan1
- Start date
I appreciate the apology but I don't appreciate being lied to. I have never once used your name on this website.
A
anon_ezos2e9wn1ob0
Guest
You can search your own posts, if you're interested in seeing.
Aug 9, Aug 11, September 1
Okay - you are clearly being deceptive with your accusation which I don't appreciate. It's not remotely the same, but I'll let it slide since it's the holiday season and we've all had enough of covid no matter how divergent our opinions on it are. In the end I want peace and unity for all.
Those posts refer a shorthand of your rivals screen name in the context of a conversation (as many others have posted over the years, such as saying "Snake" instead of "SnakeTom" or "SPK" instead of the full "SPK145"), not an attempt to identify or embarrass you in a malicious way as you did to me. You'll notice I didn't capitalize it and followed the same format you created the screen name with. To be fair though, I will edit them to include your full screen name rather than a shorthand version of what you chose as your rivals screen name.
Have a Merry Christmas.
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A
anon_ezos2e9wn1ob0
Guest
The latest from Boris Johnson. UK might have authorities "check in" on Christmas gatherings. Boris doesn't want families "mixing"
Interesting trend with Omicron in play. Hospitalizations are increasing in high vaccinated areas as well. Bad sign!
www.nbcnews.com
Charts: Covid hospitalizations are rising across the country, even in high-vaccination states
The winter Covid surge is fueling increased hospitalizations in high- and low-vaccinated areas.
I thought this was a well done comparison between omnicron and sars covid from a Infectious disease doctor from the UK. It’s somewhat technical but he does a nice job explaining in a straight forward way. Lots of unknown but still interesting to get the early thoughts on scientific data.
Submitted to the FDA today. Michael Joyner (Mayo Clinic) and Arturo Casadevall (Johns Hopkins) are both well respected experts in this area. They make some compelling points as to the shoddy and superficial WHO did in taking their position. Some good research being done here to keep people out of a hospital by transfusing CCP in an outpatient setting.
Response to the WHO recommendation on convalescent plasma use in Covid-19 from the National CCPP19 Convalescent Plasma Project Leadership Team
On December 6, the World Health Organization (WHO) updated its recommendations on COVID-19 management and recommended against the use of COVID-19 convalescent plasma (CCP) in treating any stage of COVID-19 disease. This recommendation was based on an analysis of aggregated randomized trial (RCT) data that, in the view of the WHO, did not show clear clinical benefits of CCP, although the recommendations did acknowledge evidence that CCP was effective in reducing the viral load in treated patients. As a mechanical and largely statistical exercise in which the results of all RCTs are simply tabulated and summarized, the WHO analysis is exemplary. But as a scientific examination and assessment of these RCTs, an exercise that requires digging below the surface to ask critical questions, the WHO recommendations are seriously wanting. Most importantly, the WHO recommendation ignores patient groups who may derive substantial benefit from CCP. In every RCT, the first issue to address is whether the core hypothesis motivating the RCT was in fact appropriately tested. Had the WHO dug deeper into the RCTs it would have discovered that most RCTs did not test CCP appropriately. Decades of experience have shown conclusively that for convalescent plasma to work, it must be provided early in the course of illness and with sufficient antibody content, , a principle that is supported by robust biological evidence and animal models (1). Had the WHO dug deeper into the RCTs it would have noted that nearly all RCTs were conducted in heterogenous hospitalized patient populations, often including patients who had already progressed from the viral to the inflammatory phase of COVID-19, manifested by prolonged duration of symptoms and/or a requirement for invasive oxygen supplementation. Had the WHO dug deeper into the RCTs, it also would have noted that some RCTs used CCP with an insufficient amount of antibody. Unfortunately, many CCP RCTs did not, and by virtue of their study designs could not, test the hypothesis that CCP works if provided early and in a sufficient dose. Given the catastrophic conditions caused by a global pandemic, the drive to focus treatments on the sickest of hospitalized patients was understandable, but it has been known for decades that most such patients do not benefit from convalescent plasma. The WHO chose to ignore multiple signals of CCP efficacy found in subgroups of patients in the RCTs who were treated early or in less severe stages of illness and received high titer CCP (2). The WHO chose to ignore multiple observational studies, some much larger than any published randomized RCT (3), in which careful propensity matching was employed, and CCP efficacy was demonstrated (4, 5). The WHO chose to ignore studies that showed the particular value of CCP in immunosuppressed patients (6,7). The WHO chose to ignore a carefully conducted randomized RCT of CCP from Argentina, conducted in elderly outpatients shortly after their diagnosis, that reduced progression of disease by half (8). This finding has just now been replicated in another out-patient RCT in the United States (Sullivan et al), although we recognize that this finding was not available to the WHO on December 6. A most unfortunate consequence of the WHO recommendation on CCP is that it discourages use of CCP, including in low and middle-income countries (LMIC), where it may be the only antiviral available. In comparison to all other drug or in-patient therapies, CCP is safe, relatively inexpensive and widely available, well worth the investment in making it accessible in resource-limited settings. In addition, convalescent plasma is the only treatment that can be employed rapidly in any new epidemic situation as soon as there are survivors. Its success in this setting for COVID-19 has recently been demonstrated in 2 a large RCT (9). We urge the WHO to revisit its recommendation on CCP by reviewing the totality and consistency of the evidence supporting its benefit, taking account of the pandemic conditions and the features of RCT design that affected the findings of most large RCTs. The first step should be to examine in detail the RCTs that replicated the circumstances under which convalescent plasma has worked effectively in the past. This means focusing on RCTs that administered high titer CCP early in the disease course. Such trials are consistent with both the historical use of convalescent serum and the contemporary employment of monoclonal antibodies in COVID-19. They are the most appropriate RCTs upon which any recommendation for CCP use should be based.
Nigel Paneth
Arturo Casadevall
Liise-anne Pirofski
Jeffrey H. Henderson
Brenda Grossman
Shmuel Shoham
Michael J Joyner For CCPP19.org
REFERENCES 1. Casadevall A, Pirofski LA, and Joyner MJ: The Principles of Antibody Therapy for Infectious Diseases with Relevance for COVID-19. mBio. 2021;12(2). 2. Focosi D, Franchini M, Pirofski L-a et al: COVID-19 convalescent plasma and randomized clinical trials: rebuilding confidence by explaining failures and finding signals of efficacy. medRxiv. 2021; 09.07.21263194. 3. Arnold Egloff SA, Junglen A, Restivo JS et al: Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19. The Journal of Clinical Investigation. 2021; Oct 15;131(20):e151788 4. Klassen SA, Senefeld JW, Senese KA et al: Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence. Frontiers in Medicine (Lausanne). 2021; Jun 7;8:684151 5. Klassen SA, Senefeld JW, Johnson PW et al: The Effect of Convalescent Plasma Therapy on Mortality Among Patients with COVID-19: Systematic Review and Meta-analysis. Mayo Clinic Proceedings. 2021; May;96(5):1262-1275 6. Senefeld JW, Klassen SA, Ford SK et al: Use of convalescent plasma in COVID-19 patients with immunosuppression. Transfusion. 2021; Aug;61(8):2503-2511 7. Thompson MA, Henderson JP, Shah PK et al: Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19. JAMA Oncol. 2021; Jun 17; 7(8): 1167-75 3 8. Libster R, Pérez Marc G, Wappner D et al: Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med. 2021; Feb 18;384(7):610-618. 9. Ortigoza MB, Yoon H, Goldfeld KS et al: Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial. JAMA Internal Medicine. 2021; Dec 13; doi: 10.1001/jamainternmed.2021.6850. Online ahead of print.
Response to the WHO recommendation on convalescent plasma use in Covid-19 from the National CCPP19 Convalescent Plasma Project Leadership Team
On December 6, the World Health Organization (WHO) updated its recommendations on COVID-19 management and recommended against the use of COVID-19 convalescent plasma (CCP) in treating any stage of COVID-19 disease. This recommendation was based on an analysis of aggregated randomized trial (RCT) data that, in the view of the WHO, did not show clear clinical benefits of CCP, although the recommendations did acknowledge evidence that CCP was effective in reducing the viral load in treated patients. As a mechanical and largely statistical exercise in which the results of all RCTs are simply tabulated and summarized, the WHO analysis is exemplary. But as a scientific examination and assessment of these RCTs, an exercise that requires digging below the surface to ask critical questions, the WHO recommendations are seriously wanting. Most importantly, the WHO recommendation ignores patient groups who may derive substantial benefit from CCP. In every RCT, the first issue to address is whether the core hypothesis motivating the RCT was in fact appropriately tested. Had the WHO dug deeper into the RCTs it would have discovered that most RCTs did not test CCP appropriately. Decades of experience have shown conclusively that for convalescent plasma to work, it must be provided early in the course of illness and with sufficient antibody content, , a principle that is supported by robust biological evidence and animal models (1). Had the WHO dug deeper into the RCTs it would have noted that nearly all RCTs were conducted in heterogenous hospitalized patient populations, often including patients who had already progressed from the viral to the inflammatory phase of COVID-19, manifested by prolonged duration of symptoms and/or a requirement for invasive oxygen supplementation. Had the WHO dug deeper into the RCTs, it also would have noted that some RCTs used CCP with an insufficient amount of antibody. Unfortunately, many CCP RCTs did not, and by virtue of their study designs could not, test the hypothesis that CCP works if provided early and in a sufficient dose. Given the catastrophic conditions caused by a global pandemic, the drive to focus treatments on the sickest of hospitalized patients was understandable, but it has been known for decades that most such patients do not benefit from convalescent plasma. The WHO chose to ignore multiple signals of CCP efficacy found in subgroups of patients in the RCTs who were treated early or in less severe stages of illness and received high titer CCP (2). The WHO chose to ignore multiple observational studies, some much larger than any published randomized RCT (3), in which careful propensity matching was employed, and CCP efficacy was demonstrated (4, 5). The WHO chose to ignore studies that showed the particular value of CCP in immunosuppressed patients (6,7). The WHO chose to ignore a carefully conducted randomized RCT of CCP from Argentina, conducted in elderly outpatients shortly after their diagnosis, that reduced progression of disease by half (8). This finding has just now been replicated in another out-patient RCT in the United States (Sullivan et al), although we recognize that this finding was not available to the WHO on December 6. A most unfortunate consequence of the WHO recommendation on CCP is that it discourages use of CCP, including in low and middle-income countries (LMIC), where it may be the only antiviral available. In comparison to all other drug or in-patient therapies, CCP is safe, relatively inexpensive and widely available, well worth the investment in making it accessible in resource-limited settings. In addition, convalescent plasma is the only treatment that can be employed rapidly in any new epidemic situation as soon as there are survivors. Its success in this setting for COVID-19 has recently been demonstrated in 2 a large RCT (9). We urge the WHO to revisit its recommendation on CCP by reviewing the totality and consistency of the evidence supporting its benefit, taking account of the pandemic conditions and the features of RCT design that affected the findings of most large RCTs. The first step should be to examine in detail the RCTs that replicated the circumstances under which convalescent plasma has worked effectively in the past. This means focusing on RCTs that administered high titer CCP early in the disease course. Such trials are consistent with both the historical use of convalescent serum and the contemporary employment of monoclonal antibodies in COVID-19. They are the most appropriate RCTs upon which any recommendation for CCP use should be based.
Nigel Paneth
Arturo Casadevall
Liise-anne Pirofski
Jeffrey H. Henderson
Brenda Grossman
Shmuel Shoham
Michael J Joyner For CCPP19.org
REFERENCES 1. Casadevall A, Pirofski LA, and Joyner MJ: The Principles of Antibody Therapy for Infectious Diseases with Relevance for COVID-19. mBio. 2021;12(2). 2. Focosi D, Franchini M, Pirofski L-a et al: COVID-19 convalescent plasma and randomized clinical trials: rebuilding confidence by explaining failures and finding signals of efficacy. medRxiv. 2021; 09.07.21263194. 3. Arnold Egloff SA, Junglen A, Restivo JS et al: Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19. The Journal of Clinical Investigation. 2021; Oct 15;131(20):e151788 4. Klassen SA, Senefeld JW, Senese KA et al: Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence. Frontiers in Medicine (Lausanne). 2021; Jun 7;8:684151 5. Klassen SA, Senefeld JW, Johnson PW et al: The Effect of Convalescent Plasma Therapy on Mortality Among Patients with COVID-19: Systematic Review and Meta-analysis. Mayo Clinic Proceedings. 2021; May;96(5):1262-1275 6. Senefeld JW, Klassen SA, Ford SK et al: Use of convalescent plasma in COVID-19 patients with immunosuppression. Transfusion. 2021; Aug;61(8):2503-2511 7. Thompson MA, Henderson JP, Shah PK et al: Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19. JAMA Oncol. 2021; Jun 17; 7(8): 1167-75 3 8. Libster R, Pérez Marc G, Wappner D et al: Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med. 2021; Feb 18;384(7):610-618. 9. Ortigoza MB, Yoon H, Goldfeld KS et al: Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial. JAMA Internal Medicine. 2021; Dec 13; doi: 10.1001/jamainternmed.2021.6850. Online ahead of print.
The latest from Bill. Later on in the thread he mentions he has a good feeling the pandemic will end in 2022. Does thiz people higher up already know the end game? Do they know omicron will end the pandemic? Is Biden using this as a political tool?
Interesting trend with Omicron in play. Hospitalizations are increasing in high vaccinated areas as well. Bad sign!
Charts: Covid hospitalizations are rising across the country, even in high-vaccination states
The winter Covid surge is fueling increased hospitalizations in high- and low-vaccinated areas.
Israel now recommending a FOURTH shot
Israel begins fourth Covid-19 dose vaccine rollout for people 60 and over as Omicron cases surge — CNN
Israel is to begin rolling out a fourth dose of the coronavirus vaccine with immediate effect for people ages 60 and over, medical workers and people with suppressed immune systems, the Prime Minister's Office announced Tuesday, following a recommendation from the country's panel of coronavirus...
Israel now recommending a FOURTH shot
Israel begins fourth Covid-19 dose vaccine rollout for people 60 and over as Omicron cases surge — CNN
Israel is to begin rolling out a fourth dose of the coronavirus vaccine with immediate effect for people ages 60 and over, medical workers and people with suppressed immune systems, the Prime Minister's Office announced Tuesday, following a recommendation from the country's panel of coronavirus...apple.news
YES!
I just tested positive for COVID with a rapid test I was finally able to get. I've been waiting for PCR results for almost 2 days now. Crazy delays with those and it was nearly impossible to find the rapids. Almost 100% sure I have omicron -- looking back now and seeing tons of friends/coworkers testing positive, symptoms appear to have started for me as a sudden headache and bouts of sneezing. The headache and sneezing have stopped and I have a tickle in the throat... not really sore but noticeable. No loss of taste or smell, and no fever at all. Very seldom coughing.
For reference I am under 30 and have 2 full Moderna doses plus a booster at the start of November and caught it, though fortunately with the vaccines it is not even as bad as a common cold for me. Funny enough, I've been measuring my blood O2 levels and earlier today was the first time I've ever seen it at 100%...
Sad to have to cancel holiday travel plans to be with family, but rather be safe than sorry especially with parents in the high-risk and "older" category.
For reference I am under 30 and have 2 full Moderna doses plus a booster at the start of November and caught it, though fortunately with the vaccines it is not even as bad as a common cold for me. Funny enough, I've been measuring my blood O2 levels and earlier today was the first time I've ever seen it at 100%...
Sad to have to cancel holiday travel plans to be with family, but rather be safe than sorry especially with parents in the high-risk and "older" category.Those were pretty much my symptoms. Hope you feel better. Good that you’re measuring O2 levels. If it makes you feel better I’m twice your age and bounced back fairly quickly. Merry Christmas!I just tested positive for COVID with a rapid test I was finally able to get. I've been waiting for PCR results for almost 2 days now. Crazy delays with those and it was nearly impossible to find the rapids. Almost 100% sure I have omicron -- looking back now and seeing tons of friends/coworkers testing positive, symptoms appear to have started for me as a sudden headache and bouts of sneezing. The headache and sneezing have stopped and I have a tickle in the throat... not really sore but noticeable. No loss of taste or smell, and no fever at all. Very seldom coughing.
For reference I am under 30 and have 2 full Moderna doses plus a booster at the start of November and caught it, though fortunately with the vaccines it is not even as bad as a common cold for me. Funny enough, I've been measuring my blood O2 levels and earlier today was the first time I've ever seen it at 100%...
Thanks for the well wishes, and glad you recovered quickly! I think the more annoying thing will be being cooped up and bored... you can only vacuum the floors and spray clean the counters so many times... worth it though to prevent more spread if I can. Merry Christmas!
Lol…same here. Cabin fever. I would not survive a work from home job. Talk to your physician but once I was four days in and feeling better he said it was okay to take a bike ride or light run. He said it’s like giving your lungs a workout and getting more O2. Good decision making on your part.
Interesting takes from a lot of people in power. They are not insisting 2022 will be the end of the pandemic. Even the WHO is now saying this.
US Army developing vaccine to fight ‘array’ of COVID variants
The US Army has developed a vaccine to fight all variants of COVID-19, including Omicron and Delta — as well as all prior coronaviruses and strains not yet identified.
nypost.com
Encouraging. The data does not lie unlike politicians with hidden agendas.
www.dailymail.co.uk
Boris hits brakes on Christmas curbs as scientists give Omicron hope
Boris Johnson declared last night that Christmas can definitely go ahead 'cautiously', but warned that the government is tracking the spread of the mutant strain hour by hour.
US Army developing vaccine to fight ‘array’ of COVID variants
The US Army has developed a vaccine to fight all variants of COVID-19, including Omicron and Delta — as well as all prior coronaviruses and strains not yet identified.
Why isn't this in mainstream news? Seems like a huge story.
It will be interesting to see the call DeBlasio makes on New Years Eve in Times Square (still no word), because putting people face to face in human pens for 10-12 hours in cold weather is not a possible problem?Encouraging. The data does not lie unlike politicians with hidden agendas.
Boris hits brakes on Christmas curbs as scientists give Omicron hope
Boris Johnson declared last night that Christmas can definitely go ahead 'cautiously', but warned that the government is tracking the spread of the mutant strain hour by hour.
Governor Murphy to travel to Costa Rica for Christmas while the state struggles with a "surge". Hard to take this seriously when Murphy is going to Costa Rica. Imagine if this was Desantis?
www.nj.com
Gov. Murphy to celebrate Christmas out of the country with his family
The trip comes as COVID-19 cases and hospitalizations are surging again in New Jersey.
Good for him. The only question I have with this is should he test positive in Costa Rica will he be forced to stay until he is negative. Or do the rules not apply to him? As long as the state is covered should our governor get stuck in another country for a couple weeks, let him celebrate Christmas how he wants.Governor Murphy to travel to Costa Rica for Christmas while the state struggles with a "surge". Hard to take this seriously when Murphy is going to Costa Rica. Imagine if this was Desantis?
Gov. Murphy to celebrate Christmas out of the country with his family
The trip comes as COVID-19 cases and hospitalizations are surging again in New Jersey.
Because he knows the pandemic is over.Governor Murphy to travel to Costa Rica for Christmas while the state struggles with a "surge". Hard to take this seriously when Murphy is going to Costa Rica. Imagine if this was Desantis?
Gov. Murphy to celebrate Christmas out of the country with his family
The trip comes as COVID-19 cases and hospitalizations are surging again in New Jersey.
Covid Linked Medical Issues/Deaths in Sports
Interesting.
More Interesting, and certainly would give me a pause if I were a high intensity athlete.
mRNA-LNP Study
Interesting.
More Interesting, and certainly would give me a pause if I were a high intensity athlete.
mRNA-LNP Study
NJ reports 15,000 positive cases. A staggering record for this pandemic.
Hospitalizations up over 2,000.
This pandemic is spinning out of control.
www.nj.com
Hospitalizations up over 2,000.
This pandemic is spinning out of control.
N.J. reports 15,482 COVID cases, in a tremendous jump that shattered the state record for 2nd straight day
New Jersey also reported another 33 deaths.
Another clown here. How could he possibly have contracted it with all of his great "health and safety protocols?"
www.nj.com
Jersey City Mayor Steven Fulop tests positive for COVID-19
He is asymptomatic, according to social media posts.
Not one of these clowns has embraced the things you can do on a daily basis to build your immune system and avoiding things like alcohol, marijuana, etc that bring down your immune system.Another clown here. How could he possibly have contracted it with all of his great "health and safety protocols?"
Jersey City Mayor Steven Fulop tests positive for COVID-19
He is asymptomatic, according to social media posts.
It looks like we will be locked down soon. Fauci is saying gatherings more than 40 people are dangerous.
Side note: just me or is Fauci losing it? Looks like he's angry and just yelling stuff about large gatherings in this video
Side note: just me or is Fauci losing it? Looks like he's angry and just yelling stuff about large gatherings in this video
The Garden State COVID related hospitalizations are at a 10 month high. 54% increase. I thought people on this board were saying omicron was mild. The numbers seem to be saying otherwise.
Several NJ schools are going virtual after winter break. Based on the timeline of the new surge, Paterson won't return to the end of March.
@King of S Remember when posters told me schools would never go virtual. And I said they would? I was right on that!
www.nj.com
@King of S Remember when posters told me schools would never go virtual. And I said they would? I was right on that!
As COVID cases surge, some schools will go remote in January. Here are districts’ plans.
With a spike in COVID-19 cases throughout the state, here's how school districts are responding.
Dr Fauci has said that cases will continue to skyrocket within the coming weeks. He has called anyone that is going to large gatherings such as sporting events "highly irresponsible". I hope people make a reasonable decision on what they decide to do for the next couple seton hall games!
www.cnbc.com
Fauci says Covid cases will go much higher as omicron spread continues, warns against getting complacent
Covid-19 cases are likely going to keep surging as the omicron variant spreads across the globe, Dr. Anthony Fauci said.
They said omicron would be "more mild". I said it was too early to tell. Two weeks later. Who is right again???
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